TMC Registry

Purpose

TMC Registry is designed to systematically track, monitor, and analyze the clinical data of patients diagnosed with pituitary and endocrine conditions.

Endocrine disorders are often complex and require long-term monitoring. This initiative, developed specifically for the Section of Endocrinology, Diabetes and Metabolism at The Medical City, addresses the need for a structured, longitudinal dataset that enables clinicians and researchers to study prevalence, treatment outcomes, and disease progression within our patient population.

The Registry serves as a vital resource for improving clinical care pathways and fostering internal research excellence at The Medical City.

Methodology

Data is collected prospectively by treating physicians at The Medical City through a secure, web-based platform. Each patient enrollment requires informed consent in accordance with Republic Act No. 10173 (Data Privacy Act of 2012) and the Health Privacy Code (JAO 2016-0002).

Clinical data is organized across 15 standardized domains:

1. 01Patient Demographics & Identifiers
2. 02Eligibility (Inclusion / Exclusion Criteria)
3. 03Diagnosis Metadata & Disease Timeline
4. 04Subjective Presenting Symptoms
5. 05Past Medical History & Medications
6. 06Vital Signs
7. 07Physical Examination Findings
8. 08Assessment (Functioning / Non-Functioning Adenoma, Hormone Deficiencies, Functioning Subtypes)
9. 09Management Plan (Surgery, Radiation, Medical, Observation)
10. 10Pituitary Hormone Panel & Dynamic / Confirmatory Test Results
11. 11Posterior Pituitary & Metabolic Baseline Results
12. 12Imaging Findings (MRI)
13. 13Visual Acuity & OCT (Pre- and Post-operative)
14. 14Surgery & Pathology
15. 15Clinical Outcomes

Diagnosis coding follows ICD-10 standards. Surgical grading uses Knosp and Hardy classifications for pituitary tumor extent and invasion.

Project Scope

The registry is exclusively operated within The Medical City, a tertiary hospital in Ortigas Center, Pasig City. It supports the multidisciplinary endocrine team spanning endocrinology, surgery, ophthalmology, pathology, and metabolic health specialists.

Statistics and aggregated data generated by the registry represent the clinical experience and patient outcomes specifically of The Medical City.

Project Origin & Affiliation

This registry is a specialized technical initiative developed specifically for the Section of Endocrinology, Diabetes and Metabolism at The Medical City. It serves the Section of Endocrinology, Diabetes and Metabolism as a dedicated tool for institutional data management and clinical research.

While it follows international standards and allows for collaboration with local societies like the Philippine College of Endocrinology, Diabetes and Metabolism (pCEDM), the platform is designed primarily as an internal institutional resource to support the specific needs of The Medical City.

References

1. 1.Drange MR, Fram NR, Herman-Bonert V, Melmed S. Pituitary Tumor Registry: A Novel Clinical Resource. J Clin Endocrinol Metab. 2000;85(1):168–174.
2. 2.Hernandez MAL, et al. Post-operative Outcomes of Pituitary Macroadenoma Patients in a Tertiary Hospital in the Philippines. JAFES. 2025;40(2):114–125.
3. 3.Seng KS, et al. Outcomes of Endoscopic Endonasal Transsphenoidal Surgery of Pituitary Adenomas at the Philippine General Hospital.
4. 4.Mohseni S, et al. Pituitary tumor registry: a multidisciplinary program protocol. J Diabetes Metab Disord. 2023;22:1801–1804.
5. 5.Nasution, et al. (transsphenoidal pituitary surgery electrolyte cohort). Interdiscip Neurosurg. 2024;36:101901.

Contact

For inquiries about the registry, participation, or research collaboration, please contact: